Jazz Pharmaceuticals

This website has been developed and funded by Jazz Pharmaceuticals for members of the public, patients and carers. This section contains reference information. It is not intended to replace the advice of a healthcare professional.


This page has information on a potential haematopoietic stem cell transplant complication, Veno-Occlusive Disease (VOD), and the signs and symptoms of it.


This page is to inform you about a condition called veno-occlusive disease (VOD). VOD is not very common but it can happen. The information in this page will help you to understand signs and symptoms and the importance of reporting immediately to healthcare providers.

For more information, please review the Patient Information Leaflet and Summary of Product Characteristics (SmPC) above.

This page contains reference information. It is not intended to replace the advice of a healthcare professional.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. For more information on how to report side effects, Click on Adverse Event Reporting above.


VOD happens when the small blood vessels leading into the liver and that are found inside the liver become swollen, damaged and/or blocked. This prevents the liver from carrying out its job properly, such as removing waste products from your body, and can cause problems with other organs and systems in the body.

VOD can occur as a complication of stem cell transplant and is thought to be caused by chemotherapy drugs used and radiation therapy given before transplant.

What are the signs and symptoms of VOD?


Bloated abdomen, swollen legs or hands

Weight Gain

Sudden weight gain

Pain In Top

Pain in the top right quarter of your abdomen

Yellow Eyes

Yellow eyes and skin

Dark Pee

Dark pee



nose bleeds, bleeding from the gums (particularly when brushing your teeth) or blood in spit that is coughed up

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Diagnosing and treating VOD

Healthcare teams will monitor for any signs or symptoms of VOD during stem cell transplantation.

What can be done before transplant to prevent VOD?

Healthcare teams will ask questions, do tests and physical examinations to assess the risk of developing VOD. These tests will often include taking weight, measuring around the abdomen, blood tests and a physical examination including the skin.

How can VOD be detected after transplant?

Healthcare teams will be looking out for all the key signs and symptoms for VOD. This might involve them carrying out different tests and a physical examination.

What happens when diagnosed with VOD?

Healthcare teams could offer a number of different therapies to help treat the symptoms and this can include providing you with pain killers.

VOD can occur while in hospital or after being discharged from hospital. Therefore, it is important to look out for any signs and symptoms.